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Invitrogen™ Septin 2 Recombinant Rabbit Monoclonal Antibody (9N1B3)
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Catalog No. PIMA538165
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PIMA538165 100 μL
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Catalog No. PIMA538165 Supplier Invitrogen™ Supplier No. MA538165
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Rabbit Recombinant Monoclonal Antibody

Positive Samples: PC-3, SH-SY5Y, Mouse testis, Mouse brain, Rat brain Immunogen sequence: EIEEHNIKIY HLPDAESDED EDFKEQTRLL KASIPFSVVG SNQLIEAKGK KVRGRLYPWG VVEVENPEHN DFLKLRTMLI THMQDLQEVT QDLHYEN.

Septin 2 is a filament-forming cytoskeletal GTPase. Septin 2 is required for normal organization of the actin cytoskeleton and plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. It is required for the progression through mitosis, and it forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, Septin 2 may be required for chromosome segregation and spindle elongation. Septin 2 also plays a role in ciliogenesis and collective cell movements.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Septin 2
Applications ELISA, Western Blot
Classification Recombinant Monoclonal
Clone 9N1B3
Concentration 0.53 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene SEPTIN2
Gene Accession No. P42208, Q15019, Q91Y81
Gene Alias 2-Sep; AW208991; DIFF6; hNedd5; KIAA0158; mKIAA0158; NEDD5; Nedd-5; Neural precursor cell expressed developmentally down-regulated protein 5; neural precursor cell expressed, developmentally down-regulated 5; neural precursor cell expressed, developmentally down-regulated gene 5; Pnutl3; Sept2; septin 2; Septin2; septin-2; Vascular endothelial cell specific protein 11; Vesp11
Gene Symbols SEPTIN2
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 202-298 of human Septin 2 (Q15019).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 117515, 18000, 4735
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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