Invitrogen™ Septin-9 Polyclonal Antibody

Catalog No.	Quantity
PIPA583619	100 μL

Catalog No. PIPA583619 Supplier Invitrogen™ Supplier No. PA583619

Description

Rabbit Polyclonal Antibody

Immunogen sequence: LGVKNSEPSA RHVDSLSQRS PKASLRRVEL SGPKAAEPVS RRTELSIDIS SKQVENAGAI GPSRFGLKRA EVLGHKTPEP APRRTEITIV KPQESA Highest antigen sequence indentity to the following orthologs: Mouse - 86%, Rat - 84%.

The maf oncogene was identified by structural analysis of the AS42 avian transforming retrovirus genome. The Maf family is divided into two subclasses, large Mafs (vMaf, cMaf, MafB and Nrl) and small Mafs (MafF, MafK, and MafG). Both subclasses contain leucinezipper motifs, which allow homodimerization as well as heterodimerization with a variety of other bZip transcription factors. Large Mafs also contain an acidic transactivation domain absent in the small Maf proteins. Although they do not possess inherent transactivation activity, small Maf proteins can act as positive regulators of transcription by targeting transcriptionally active dimerization partners to specific DNA regulatory elements. Conversely, small Mafs can act also as negative regulators of transcription by recruiting transcriptional repressors or by forming homodimers that can replace active dimers. Human MafF was isolated in a yeast one-hybrid system from a human myometrium cDNA library. Human MAFF encodes a 164 amino acids proten. Like other small MAFF proteins, it contains an extended leucine zipper structure and lacks an N-terminal transactivating domain. The three small Maf proteins have been implicated in a number of physiological processes, including development, differentiation, haematopoiesis and stress response. Interestingly, these three proteins regulate the stress response via different mechanisms.

Specifications

• Antigen: Septin-9
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.3 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: SEPTIN9
• Gene Accession No.: Q9UHD8
• Gene Alias: AF17q25; eighth septin; Eseptin; E-septin; KIAA0991; MLL septin-like fusion; MLL septin-like fusion protein; MLL septin-like fusion protein MSF-A; MSF; MSF1; NAPB; Ov/Br septin; ovarian/breast septin; PNUTL4; SEPT9; SeptD1; septin 9; septin D1; SEPTIN9; Septin-9; septin-like protein; Sint1; SL3-3 integration site 1 protein; SLP; Slpa
• Gene Symbols: SEPTIN9
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to Human SEPT9. Recombinant protein control fragment (Product #RP-99957).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 10801
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG