Invitrogen™ SERF1A Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA567379

Catalog No. PIPA567379

Description

Immunogen sequence: SSGGQKSESKM SAGPHLPLKA PRENPCFPLP AAGGSR Highest antigen sequence identity to the following orthologs - mouse 38%, rat 38%.

This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The duplication region includes both a telomeric and a centromeric copy of this gene. Deletions of this gene, the telomeric copy, often accompany deletions of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients, and so it is thought that this gene may be a modifier of the SMA phenotype. The function of this protein is not known; however, it bears low-level homology with the RNA-binding domain of matrin-cyclophilin, a protein which colocalizes with small nuclear ribonucleoproteins (snRNPs) and the SMN1 gene product. Alternatively spliced transcripts have been documented but it is unclear whether alternative splicing occurs for both the centromeric and telomeric copies of the gene. [provided by RefSeq, Jul 2008].

Specifications

• Antigen: SERF1A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SERF1A
• Gene Alias: 4F5; FAM2A; FAM2B; h4F5; protein 4F5; SERF1; SERF1A; SERF1B; SMA modifier 1; small EDRK-rich factor 1; small EDRK-rich factor 1A; small EDRK-rich factor 1A (telomeric); small EDRK-rich factor 1B (centromeric); SMAM1; spinal muscular atrophy-related gene H4F5; Unknown (protein for MGC:133508)
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8293
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O75920
• Gene Symbols: SERF1A
• Immunogen: Recombinant Human SERF1A. Recombinant protein control fragment (Product #RP-105668).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG