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MilliporeSigma™ Serotonin Receptor 1B, Mouse, Unlabeled, Clone: 1C2.1,

Catalog No. MABN1539MI Shop All MilliporeSigma Products
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Quantity:
100 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
MABN1539MI 100 μg Unconjugated
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Catalog No. MABN1539MI Supplier MilliporeSigma™ Supplier No. MABN1539
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Description

Mouse Monoclonal Antibody

5-hydroxytryptamine receptor 1B (UniProt P28222; also known as 5-HT-1B, 5-HT-1D-beta, 5-HT1B, S12, Serotonin 1D beta receptor, Serotonin receptor 1B) is encoded by the HTR1B (also known as HTR1DB) gene (Gene ID 3351) in human. The 5-HT receptors are grouped according to their antagonist susceptibilities and their affinities for 5-HT. The 5-HT1 receptors are a subfamily of 5-HT receptors that were originally classified according to their inhibition of adenylyl cyclase, degree of sequence similarity and their overlapping pharmacological specificities. The subfamily has five different receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT1F that can couple to Gi/Go and mediate inhibitory neurotransmission. 5HT-1B receptor belong to the family of G-protein coupled receptors that are distributed in brain cortex, striatum, amygdala, medulla, hippocampus, caudate nucleus and putamen. 5-HT-1B also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide. Ligand binding causes a conformation change in the receptor that triggers signaling via G-proteins, which modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling via 5-HT-1B inhibits adenylate cyclase activity. 5-HT1B receptor is known to be involved in thermoregulation, respiration, appetite control, sexual behavior, and aggression. 5-HT-1B receptor are therapeutic targets for antimigraine drugs and for treatment of bipolar disorders, autism, and anti-aggressive agents.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Serotonin Receptor 1B
Applications Western Blot
Classification Monoclonal
Clone 1C2.1
Concentration Please refer to lot specific datasheet.
Conjugate Unconjugated
Formulation Purified mouse IgG1 in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene HTR1B, HTR1DB
Gene Accession No. P28222
Host Species Mouse
Immunogen GST-tagged recombinant fragment corresponding to the thrid cytoplasmic domain of human serotonin receptor 1B.
Purification Method Protein G Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Neuroscience
Primary or Secondary Primary
Gene ID (Entrez) NP_000854
Test Specificity Clone 1C2.1 targets an epitope within the third cytoplasmic domain of human, mouse, and rat serotonin receptor 1B.
Target Species Human
Content And Storage Stable for 1 year at 2°-8°C from date of receipt.
Form Purified
Isotype IgG1 κ
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For Research Use Only. Not for use in diagnostic procedures.

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