MilliporeSigma™ Serotonin Receptor 1B, Mouse, Unlabeled, Clone: 1C2.1,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ MABN1539

Catalog No. MABN1539MI

Description

5-hydroxytryptamine receptor 1B (UniProt P28222; also known as 5-HT-1B, 5-HT-1D-beta, 5-HT1B, S12, Serotonin 1D beta receptor, Serotonin receptor 1B) is encoded by the HTR1B (also known as HTR1DB) gene (Gene ID 3351) in human. The 5-HT receptors are grouped according to their antagonist susceptibilities and their affinities for 5-HT. The 5-HT1 receptors are a subfamily of 5-HT receptors that were originally classified according to their inhibition of adenylyl cyclase, degree of sequence similarity and their overlapping pharmacological specificities. The subfamily has five different receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT1F that can couple to Gi/Go and mediate inhibitory neurotransmission. 5HT-1B receptor belong to the family of G-protein coupled receptors that are distributed in brain cortex, striatum, amygdala, medulla, hippocampus, caudate nucleus and putamen. 5-HT-1B also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide. Ligand binding causes a conformation change in the receptor that triggers signaling via G-proteins, which modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling via 5-HT-1B inhibits adenylate cyclase activity. 5-HT1B receptor is known to be involved in thermoregulation, respiration, appetite control, sexual behavior, and aggression. 5-HT-1B receptor are therapeutic targets for antimigraine drugs and for treatment of bipolar disorders, autism, and anti-aggressive agents.

Specifications

• Antigen: Serotonin Receptor 1B
• Classification: Monoclonal
• Concentration: Please refer to lot specific datasheet.
• Formulation: Purified mouse IgG1 in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
• Gene Accession No.: P28222
• Immunogen: GST-tagged recombinant fragment corresponding to the thrid cytoplasmic domain of human serotonin receptor 1B.
• Quantity: 100 μg
• Research Discipline: Neuroscience
• Gene ID (Entrez): NP_000854
• Target Species: Human
• Form: Purified

• Applications: Western Blot
• Clone: 1C2.1
• Conjugate: Unconjugated
• Gene: HTR1B, HTR1DB
• Host Species: Mouse
• Purification Method: Protein G Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Clone 1C2.1 targets an epitope within the third cytoplasmic domain of human, mouse, and rat serotonin receptor 1B.
• Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
• Isotype: IgG1 κ

For Research Use Only. Not for use in diagnostic procedures.