SERPINA1 Mouse anti-Canine, Human, Clone: OTI5B12, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF500371

Catalog No. 50-165-9450

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Alpha-1-AT is synthesized in the liver and it acts as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung. In the absence of alpha-1-AT, these enzymes are not inhibited and they may digest pulmonary parenchyma. Alpha-1-AT deficiency is associated with chronic obstructive lung disease (emphysema) and less frequently with hepatic cirrhosis in infants and respiratory distress of the newborn. Increase in alpha-1-AT occurs as an acute phase response to tissue necrosis and inflammation. Serum level of alpha-1-AT is elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.

Specifications

• Antigen: SERPINA1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: SERPINA1
• Gene Alias: A1A, A1AT, AAT, PI, PI1, PRO2275, alpha1AT, nNIF
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 480422, 5265
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Clone: OTI5B12
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: P01009
• Gene Symbols: SERPINA1
• Immunogen: Full length human recombit protein of human SERPINA1 produced in HEK293T cell.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Canine, Human
• Product Type: Antibody
• Isotype: IgG1