SERPINA1 Mouse anti-Human, Biotin, Clone: OTI5B12, liquid, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene TA700007

Catalog No. 50-167-7580

Description

Alpha-1-AT is synthesized in the liver and it acts as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung. In the absence of alpha-1-AT, these enzymes are not inhibited and they may digest pulmonary parenchyma. Alpha-1-AT deficiency is associated with chronic obstructive lung disease (emphysema) and less frequently with hepatic cirrhosis in infants and respiratory distress of the newborn. Increase in alpha-1-AT occurs as an acute phase response to tissue necrosis and inflammation. Serum level of alpha-1-AT is elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.

Specifications

• Antigen: SERPINA1
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 10mg/ml BSA, 50% glycerol and 0.05% sodium azide
• Gene Accession No.: P01009
• Gene Symbols: SERPINA1
• Immunogen: Protein expressed in 293T cell transfected with human SERPINA1 expression vector
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA
• Clone: OTI5B12
• Conjugate: Biotin
• Gene: SERPINA1
• Gene Alias: A1A, A1AT, AAT, PI, PI1, PRO2275, alpha1AT, nNIF
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5265
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid