SERPINA1 Mouse anti-Human, Clone: OTI11G2, liquid, TrueMAB™

Catalog No.	Quantity
50-167-7126	100 μg

Catalog No. 50-167-7126 Supplier OriGene Supplier No. TA600007

Description

Mouse Monoclonal Antibody

Alpha-1-AT is synthesized in the liver and it acts as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung. In the absence of alpha-1-AT, these enzymes are not inhibited and they may digest pulmonary parenchyma. Alpha-1-AT deficiency is associated with chronic obstructive lung disease (emphysema) and less frequently with hepatic cirrhosis in infants and respiratory distress of the newborn. Increase in alpha-1-AT occurs as an acute phase response to tissue necrosis and inflammation. Serum level of alpha-1-AT is elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.

Specifications

• Antigen: SERPINA1
• Applications: ELISA
• Classification: Monoclonal
• Clone: OTI11G2
• Conjugate: Unconjugated
• Formulation: PBS with <5% trehalose and 0.05% sodium azide
• Gene: SERPINA1
• Gene Accession No.: P01009
• Gene Alias: A1A, A1AT, AAT, PI, PI1, PRO2275, alpha1AT, nNIF
• Gene Symbols: SERPINA1
• Host Species: Mouse
• Immunogen: Protein expressed in 293T cell transfected with human SERPINA1 expression vector
• Purification Method: Affinity Chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5265
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1