Invitrogen™ SERPINB6 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA522354

Catalog No. PIPA522354

Description

Recommended positive controls: A549, HeLa, HepG2, HCT116. Predicted reactivity: Rhesus Monkey (95%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The protein encoded by this gene is a member of the serpin superfamily, and ovalbumin-serpin subfamily. It was originally discovered as a placental thrombin inhibitor. The mouse homolog was found to be expressed in the hair cells of the inner ear. Mutations in this gene are associated with nonsyndromic progressive hearing loss, suggesting that this serpin plays an important role in the inner ear in the protection against leakage of lysosomal content during stress, and that loss of this protection results in cell death and sensorineural hearing loss. Alternatively spliced transcript variants have been found for this gene.

Specifications

• Antigen: SERPINB6
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SERPINB6
• Gene Alias: 4930482L21Rik; CAP; Cytoplasmic antiproteinase; D330015H01Rik; DFNB91; DKFZp686I04222; MGC111370; MSTP057; ovalbumin; Peptidase inhibitor 6; PI6; PI-6; Placental thrombin inhibitor; protease inhibitor 6 (placental thrombin inhibitor); proteinase inhibitor 6; PTI; QtsA-17114; RP1-90J20.6; serine (or cysteine) peptidase inhibitor, clade B, member 6a; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 6; serine (or cysteine) proteinase inhibitor, clade B, member 6a; serine protease inhibitor 3; serine proteinase inhibitor B-43; Serpin B6; serpin family B member 6; serpin peptidase inhibitor, clade B (ovalbumin), member 6; Serpinb6; Serpinb6a; Spi3; thrombin inhibitor; unnamed protein product
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 286854, 5269
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: O02739, P35237
• Gene Symbols: SERPINB6
• Immunogen: Recombinant protein encompassing a sequence within the center region of human SERPINB6. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Bovine
• Product Type: Antibody
• Isotype: IgG