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Invitrogen™ SERPINB7 Polyclonal Antibody
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Catalog No. PIPA575531
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100 μL
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PIPA575531 100 μL
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Catalog No. PIPA575531 Supplier Invitrogen™ Supplier No. PA575531
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Description

Rabbit Polyclonal Antibody

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Megsin, also designated SerpinB7 and TP55, is a 380 amino acid cytoplasmic protein that is predominantly expressed in mesangial cells, which play an important role in maintaining glomerular structure and function. As a member of the serpin family, megsin is a serine protesase inhibitor which potentially inactivate MMP-2, MMP-9 and plasmin, proteins that are notably responsible for degradation of extracellular matrix. Overexpression of megsin results in an increase in number of mesangial cells and therefore a progressive mesangial matrix expansion, which is accompanied by immune complex deposition. This finding suggests that megsin significantly influences the role of mesangial cells in renal structure and is likely implicated in a variety of nephropathies.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SERPINB7
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene SERPINB7
Gene Accession No. O75635, Q9D695
Gene Alias 4631416M05Rik; MEGSIN; mesangium predominant gene, megsin; ovalbumin; PPKN; serine (or cysteine) peptidase inhibitor, clade B, member 7; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 7; serine (or cysteine) proteinase inhibitor, clade B, member 7; serpin B7; serpin family B member 7; serpin peptidase inhibitor, clade B (ovalbumin), member 7; SERPINB7; Serpin-B7; TP55
Gene Symbols SERPINB7
Host Species Rabbit
Immunogen Synthetic peptide corresponding to amino acids 157-202 of Human SERPINB7.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 116872, 117092, 8710
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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