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Invitrogen™ SERPINB7 Polyclonal Antibody
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Catalog No. PIPA5101878
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100 μL
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PIPA5101878 100 μL
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Catalog No. PIPA5101878 Supplier Invitrogen™ Supplier No. PA5101878
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total SERPINB7.

Megsin, also designated SerpinB7 and TP55, is a 380 amino acid cytoplasmic protein that is predominantly expressed in mesangial cells, which play an important role in maintaining glomerular structure and function. As a member of the serpin family, megsin is a serine protesase inhibitor which potentially inactivate MMP-2, MMP-9 and plasmin, proteins that are notably responsible for degradation of extracellular matrix. Overexpression of megsin results in an increase in number of mesangial cells and therefore a progressive mesangial matrix expansion, which is accompanied by immune complex deposition. This finding suggests that megsin significantly influences the role of mesangial cells in renal structure and is likely implicated in a variety of nephropathies.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SERPINB7
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene SERPINB7
Gene Accession No. O75635
Gene Alias 4631416M05Rik; MEGSIN; mesangium predominant gene, megsin; ovalbumin; PPKN; serine (or cysteine) peptidase inhibitor, clade B, member 7; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 7; serine (or cysteine) proteinase inhibitor, clade B, member 7; serpin B7; serpin family B member 7; serpin peptidase inhibitor, clade B (ovalbumin), member 7; SERPINB7; Serpin-B7; TP55
Gene Symbols SERPINB7
Host Species Rabbit
Immunogen A synthesized peptide derived from human SERPINB7(Accession O75635), corresponding to amino acid residues D113-I163.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8710
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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