Invitrogen™ SERPINB9 Monoclonal Antibody (PI9-17)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA135771

Catalog No. 01-672-076

Description

The human intracellular serpin proteinase inhibitor 9 (PI9) is the only human protein able to inhibit the activity of the serine protease granzyme B. Granzyme B is expressed by cytotoxic lymphocytes and induces rapid target cell apoptosis. PI9-17 Mab was selected after immunization with full length recombinant PI9 produced in Escherichia coli. No cross reactivity with other, homologous serpins (PI6, PI8 and PAI-2) was observed.

PI9 belongs to the large superfamily of serine proteinase inhibitors (serpins), which bind to and inactivate serine proteinases. These interactions are involved in many cellular processes, including coagulation, fibrinolysis, complement fixation, matrix remodeling, and apoptosis (Sprecher et al., 1995 [PubMed 8530382]).

Specifications

• Antigen: SERPINB9
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: tissue culture supernatant with 0.7% BSA and 0.1% sodium azide
• Gene Accession No.: P50453
• Gene Symbols: SERPINB9
• Immunogen: Recombinant human full-lengthPI9 (proteinase inhibitor 9).
• Regulatory Status: RUO
• Gene ID (Entrez): 5272
• Content And Storage: 4°C
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Clone: PI9-17
• Conjugate: Unconjugated
• Gene: SERPINB9
• Gene Alias: BB283241; CAP3; CAP-3; Cytoplasmic antiproteinase 3; ovalbumin; peptidase inhibitor 9; PI9; PI-9; protease inhibitor 9 (ovalbumin type); serine (or cysteine) peptidase inhibitor, clade B, member 9; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 9; serine (or cysteine) proteinase inhibitor, clade B, member 9; serine protease inhibitor 6; serpin B9; serpin family B member 9; serpin peptidase inhibitor, clade B (ovalbumin), member 9; serpin peptidase inhibitor, clade B, member 9; SERPINB9; Spi6; testicular tissue protein Li 180
• Host Species: Mouse
• Quantity: 1 mL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1