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Invitrogen™ SERTAD1 Polyclonal Antibody
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Catalog No. PIPA5103167
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PIPA5103167 100 μL
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Catalog No. PIPA5103167 Supplier Invitrogen™ Supplier No. PA5103167
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total SEI-1.

SEI-1, also known as SERTAD1 (SERTA domain containing 1) or TRIP-Br1 (Transcriptional regulator interacting with the PHD-bromodomain 1), is a transcriptional regulator that integrates signals provided by transcription factors. Acting at E2F-responsive promoters, SEI-1 interacts with the PHD- and bromodomains of proteins such as TIF1 and DP-1, thereby transmitting their signals to the promoter and stimulating transcriptional activity. SEI-1 exists as a multiprotein complex with E2F-1 and DP-1 and is expressed at different levels throughout the cell cycle, allowing it to regulate cell cycle progression via promoter control during the G1 and S phases. Additionally, SEI-1 can render the activity of the cyclin D-Cdk4 complex, an important catalyst of the cell cycle, resistant to the inhibitory effects of p16. Overexpression of SEI-1 is implicated in the development of squamous cell carcinomas of the head and neck.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SERTAD1
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene SERTAD1
Gene Accession No. Q9UHV2
Gene Alias 1110032C13Rik; AV000455; AW456625; CDK4-binding protein p34SEI; CDK4-binding protein p34SEI1; p34SEI-1; PHD zinc finger- and bromodomain-interacting protein 1; SEI1; SEI-1; SERTA domain containing 1; SERTA domain-containing protein 1; SERTAD1; Transcriptional regulator interacting with the PHD-bromodomain 1; TRIPBR1; TRIP-Br1
Gene Symbols SERTAD1
Host Species Rabbit
Immunogen A synthesized peptide derived from human SERTAD1(Accession Q9UHV2), corresponding to amino acid residues G139-P189.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 29950
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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