Invitrogen™ SERTAD1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA566571

Catalog No. PIPA566571

Description

Immunogen sequence: TSMYDNELWAP ASEGLKPGPE DGPGKEEAPE LDEAELDYLM DVLVGTQALE RP Highest antigen sequence identity to the following orthologs - mouse 91%, rat 89%.

SEI-1, also known as SERTAD1 (SERTA domain containing 1) or TRIP-Br1 (Transcriptional regulator interacting with the PHD-bromodomain 1), is a transcriptional regulator that integrates signals provided by transcription factors. Acting at E2F-responsive promoters, SEI-1 interacts with the PHD- and bromodomains of proteins such as TIF1 and DP-1, thereby transmitting their signals to the promoter and stimulating transcriptional activity. SEI-1 exists as a multiprotein complex with E2F-1 and DP-1 and is expressed at different levels throughout the cell cycle, allowing it to regulate cell cycle progression via promoter control during the G1 and S phases. Additionally, SEI-1 can render the activity of the cyclin D-Cdk4 complex, an important catalyst of the cell cycle, resistant to the inhibitory effects of p16. Overexpression of SEI-1 is implicated in the development of squamous cell carcinomas of the head and neck.

Specifications

• Antigen: SERTAD1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SERTAD1
• Gene Alias: 1110032C13Rik; AV000455; AW456625; CDK4-binding protein p34SEI; CDK4-binding protein p34SEI1; p34SEI-1; PHD zinc finger- and bromodomain-interacting protein 1; SEI1; SEI-1; SERTA domain containing 1; SERTA domain-containing protein 1; SERTAD1; Transcriptional regulator interacting with the PHD-bromodomain 1; TRIPBR1; TRIP-Br1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 29950
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9UHV2
• Gene Symbols: SERTAD1
• Immunogen: Recombinant Human SERTAD1. Recombinant protein control fragment (Product #RP-107226).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov