Sertad1 Rabbit anti-Human, Polyclonal, Bioss
Rabbit Polyclonal Antibody
Manufacturer: Bioss BS6691R
DescriptionSEI-1, also known as SERTAD1 (SERTA domain containing 1) or TRIP-Br1 (Transcriptional regulator interacting with the PHD-bromodomain 1), is a transcriptional regulator that integrates signals provided by transcription factors. Acting at E2F-responsive promoters, SEI-1 interacts with the PHD- and bromodomains of proteins such as TIF1 and DP-1, thereby transmitting their signals to the promoter and stimulating transcriptional activity. SEI-1 exists as a multiprotein complex with E2F-1 and DP-1 and is expressed at different levels throughout the cell cycle, allowing it to regulate cell cycle progression via promoter control during the G1 and S phases. Additionally, SEI-1 can render the activity of the cyclin D-Cdk4 complex, an important catalyst of the cell cycle, resistant to the inhibitory effects of p16. Overexpression of SEI-1 is implicated in the development of squamous cell carcinomas of the head and neck.
|Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH|
|1110032C13Rik; AV000455; AW456625; CDK4-binding protein p34SEI; CDK4-binding protein p34SEI1; p34SEI-1; PHD zinc finger- and bromodomain-interacting protein 1; SEI1; SEI-1; SERTA domain containing 1; SERTA domain-containing protein 1; SERTAD1; Transcriptional regulator interacting with the PHD-bromodomain 1; TRIPBR1; TRIP-Br1|
|KLH conjugated synthetic peptide derived from human Sertad1.|