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Invitrogen™ SETD8 Monoclonal Antibody (B.540.4)

Rabbit Monoclonal Antibody

Supplier:  Invitrogen™ MA514804

Catalog No. PIMA514804


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Description

Description

It is not recommended to aliquot this antibody.

SETD8 is a histone methyltransferase that specifically monomethylates 'Lys-20' of histone H4. H4 'Lys-20' monomethylation is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. The protein mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. It is required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNA during mitosis. It is also involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

SETD8
Monoclonal
25 μg/mL
0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and <0.02% sodium azide; pH 7.5
Q2YDW7, Q9NQR1
KMT5A
Synthetic peptide corresponding to human SET8 protein.
100 μL
Primary
Human, Mouse, Rat, Monkey
Antibody
IgG
Western Blot, Immunocytochemistry
B.540.4
Unconjugated
KMT5A
2410195B05Rik; AA617402; AW536475; H4-K20-HMTase; H4-K20-HMTase KMT5A; H4-K20-HMTase SETD8; H4-K20-specific histone methyltransferase; H4K20-specific histone methyltransferase splice variant Set8b; histone methyltransferase Pr-set7/Set8; histone-lysine N-methyltransferase KMT5A; histone-lysine N-methyltransferase SETD8; KMT5A; lysine (K)-specific methyltransferase 5A; lysine methyltransferase 5A; lysine N-methyltransferase 5A; Lysine-specific methylase 5A; N-lysine methyltransferase KMT5A; N-lysine methyltransferase SETD8; PR/SET domain containing protein 8; PR/SET domain-containing protein 07; PR/SET07; PRSET7; PR-Set7; RGD1305893; SET domain containing (lysine methyltransferase) 8; SET domain containing protein 8 variant 1; SET domain containing protein 8 variant 2; SET domain-containing 8; SET domain-containing protein 8; SET07; SET8; SETD8; Unknown (protein for MGC:134426)
Rabbit
Antigen Affinity Chromatography
RUO
387893, 67956, 689820
-20°C
Liquid
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