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Active Motif SET8 / PR-SET7 Polyclonal Antibody

Catalog No. IEC61009
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100 μL
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IEC-61009 100 μL
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Catalog No. IEC-61009 Supplier Active Motif Supplier No. 61009

Description

Rabbit Polyclonal Antibody

SET8 / PR-SET7 Polyclonal Antibody for Western Blot

SETD8 is a histone methyltransferase that specifically monomethylates 'Lys-20' of histone H4. H4 'Lys-20' monomethylation is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. The protein mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. It is required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNA during mitosis. It is also involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SET8 / PR-SET7
Applications Western Blot
Classification Polyclonal
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation 70mM tris with 0.07mM EDTA, 30% glycerol, 31mM glycine, 105mM NaCl and 0.035% sodium azide; pH 8
Gene KMT5A
Gene Accession No. Q9NQR1
Gene Alias 2410195B05Rik; AA617402; AW536475; H4-K20-HMTase; H4-K20-HMTase KMT5A; H4-K20-HMTase SETD8; H4-K20-specific histone methyltransferase; H4K20-specific histone methyltransferase splice variant Set8b; histone methyltransferase Pr-set7/Set8; histone-lysine N-methyltransferase KMT5A; histone-lysine N-methyltransferase SETD8; KMT5A; lysine (K)-specific methyltransferase 5A; lysine methyltransferase 5A; lysine N-methyltransferase 5A; Lysine-specific methylase 5A; N-lysine methyltransferase KMT5A; N-lysine methyltransferase SETD8; PR/SET domain containing protein 8; PR/SET domain-containing protein 07; PR/SET07; PRSET7; PR-Set7; RGD1305893; SET domain containing (lysine methyltransferase) 8; SET domain containing protein 8 variant 1; SET domain containing protein 8 variant 2; SET domain-containing 8; SET domain-containing protein 8; SET07; SET8; SETD8; Unknown (protein for MGC:134426)
Gene Symbols KMT5A
Host Species Rabbit
Immunogen This SET8 / PR-SET7 antibody was raised against a peptide corresponding to amino acids within the N-terminal half of human SETD8.
Purification Method Antigen affinity chromatography, Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 387893
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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