Invitrogen™ SETD1B Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA540072

Catalog No. PA540072

Description

SETD1B Polyclonal Antibody for Western Blot, ELISA

Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway is reliant on members of the Toll-like receptor (TLR) family while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA as a trigger for the immune response. VISA is a mitochondrial membrane protein that was identified as a critical component in the IFN-b signaling pathways that recruits IRF-3 to RIG-I, leading to its activation and that of NF-kappa-B. VISA is also thought to interact with other components of the innate immune pathway such as the TLR adapter protein TRIF, TRAF2 and TRAF6. VISA also interacts with the IKK-a, IKK-b and IKK-iota kinases through its C-terminal region. Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to escape the host immune system. At least three isoforms of VISA are known to exist.

Specifications

• Antigen: SETD1B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Setd1b
• Gene Alias: AA516740; BC035291; Histone-lysine N-methyltransferase SETD1B; hSET1B; Kiaa1076; KMT2G; LOC100359816; Lysine N-methyltransferase 2G; mKIAA1076; rCG21620-like; SET domain containing 1B; SET domain-containing protein 1B; SET1B; SETD1B
• Host Species: Rabbit
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Western Blot
• Concentration: Conc. Not Determined
• Formulation: Whole serum with 0.05% sodium azide
• Gene Accession No.: Q8CFT2
• Gene Symbols: Setd1b
• Immunogen: KLH-conjugated synthetic peptides containing sequences from the central part of the protein corresponding to mouse Setd1b (Set domain containing 1B).
• Regulatory Status: RUO
• Gene ID (Entrez): 208043
• Content And Storage: -20°C or -80°C if preferred
• Form: Liquid