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Invitrogen™ SETD1B Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA540072
Description
SETD1B Polyclonal Antibody for Western Blot, ELISA
Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway is reliant on members of the Toll-like receptor (TLR) family while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA as a trigger for the immune response. VISA is a mitochondrial membrane protein that was identified as a critical component in the IFN-b signaling pathways that recruits IRF-3 to RIG-I, leading to its activation and that of NF-kappa-B. VISA is also thought to interact with other components of the innate immune pathway such as the TLR adapter protein TRIF, TRAF2 and TRAF6. VISA also interacts with the IKK-a, IKK-b and IKK-iota kinases through its C-terminal region. Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to escape the host immune system. At least three isoforms of VISA are known to exist.
Specifications
SETD1B | |
Polyclonal | |
Unconjugated | |
Setd1b | |
AA516740; BC035291; Histone-lysine N-methyltransferase SETD1B; hSET1B; Kiaa1076; KMT2G; LOC100359816; Lysine N-methyltransferase 2G; mKIAA1076; rCG21620-like; SET domain containing 1B; SET domain-containing protein 1B; SET1B; SETD1B | |
Rabbit | |
100 μL | |
Primary | |
Mouse | |
Antibody | |
IgG |
ELISA, Western Blot | |
Conc. Not Determined | |
Whole serum with 0.05% sodium azide | |
Q8CFT2 | |
Setd1b | |
KLH-conjugated synthetic peptides containing sequences from the central part of the protein corresponding to mouse Setd1b (Set domain containing 1B). | |
RUO | |
208043 | |
-20°C or -80°C if preferred | |
Liquid |
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