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Invitrogen™ SETD1B Polyclonal Antibody

Catalog No. PA540072
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100 μL
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PA540072 100 μL
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Catalog No. PA540072 Supplier Invitrogen™ Supplier No. PA540072
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Description

Rabbit Polyclonal Antibody

SETD1B Polyclonal Antibody for Western Blot, ELISA

Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway is reliant on members of the Toll-like receptor (TLR) family while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA as a trigger for the immune response. VISA is a mitochondrial membrane protein that was identified as a critical component in the IFN-b signaling pathways that recruits IRF-3 to RIG-I, leading to its activation and that of NF-kappa-B. VISA is also thought to interact with other components of the innate immune pathway such as the TLR adapter protein TRIF, TRAF2 and TRAF6. VISA also interacts with the IKK-a, IKK-b and IKK-iota kinases through its C-terminal region. Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to escape the host immune system. At least three isoforms of VISA are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SETD1B
Applications ELISA, Western Blot
Classification Polyclonal
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation Whole serum with 0.05% sodium azide
Gene Setd1b
Gene Accession No. Q8CFT2
Gene Alias AA516740; BC035291; Histone-lysine N-methyltransferase SETD1B; hSET1B; Kiaa1076; KMT2G; LOC100359816; Lysine N-methyltransferase 2G; mKIAA1076; rCG21620-like; SET domain containing 1B; SET domain-containing protein 1B; SET1B; SETD1B
Gene Symbols Setd1b
Host Species Rabbit
Immunogen KLH-conjugated synthetic peptides containing sequences from the central part of the protein corresponding to mouse Setd1b (Set domain containing 1B).
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 208043
Target Species Mouse
Content And Storage -20°C or -80°C if preferred
Product Type Antibody
Form Liquid
Isotype IgG
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