Invitrogen™ SETD1B Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA566255

Catalog No. PIPA566255

Description

Immunogen sequence: GLQFVNLPPYR GPFSLSNSGP GRGQHWPPLP KFDPSVPPPG YMPRQEDPHK ATVDGVLLVV LKELKAIMK Highest antigen sequence identity to the following orthologs - mouse 97%, rat 97%.

Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway is reliant on members of the Toll-like receptor (TLR) family while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA as a trigger for the immune response. VISA is a mitochondrial membrane protein that was identified as a critical component in the IFN-b signaling pathways that recruits IRF-3 to RIG-I, leading to its activation and that of NF-kappa-B. VISA is also thought to interact with other components of the innate immune pathway such as the TLR adapter protein TRIF, TRAF2 and TRAF6. VISA also interacts with the IKK-a, IKK-b and IKK-iota kinases through its C-terminal region. Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to escape the host immune system. At least three isoforms of VISA are known to exist.

Specifications

• Antigen: SETD1B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Setd1b
• Gene Alias: AA516740; BC035291; Histone-lysine N-methyltransferase SETD1B; hSET1B; Kiaa1076; KMT2G; LOC100359816; Lysine N-methyltransferase 2G; mKIAA1076; rCG21620-like; SET domain containing 1B; SET domain-containing protein 1B; SET1B; SETD1B
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23067
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9UPS6
• Gene Symbols: Setd1b
• Immunogen: Recombinant Human SETD1B. Recombinant protein control fragment (Product #RP-106936).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG