SETD2 Monoclonal Antibody (OTI3G8), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA804268

Catalog No. 50-168-0169

Description

Histone methyltransferase that specifically trimethylates ′Lys-36′ of histone H3 (H3K36me3) using dimethylated ′Lys-36′ (H3K36me2) as substrate. Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation. Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A. Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction. H3K36me3 also plays an essential role in the maintece of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A. H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase. Required during angiogenesis. Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression.

Specifications

• Antigen: SETD2
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q9BYW2
• Gene Symbols: SETD2
• Immunogen: Human recombit protein fragment corresponding to amino acids 1787-2144 of human SETD2 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: OTI3G8
• Conjugate: Unconjugated
• Gene: SETD2
• Gene Alias: HBP231, HIF-1, HIP-1, HSPC069, HYPB, KMT3A, LLS, SET2, p231HBP
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 29072
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid