Invitrogen™ SETD2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA588104

Catalog No. PIPA588104

Description

Immunogen sequence: QNRPDSRLGK TELSFSSSCE IPHVDGLHSS EELRNLGWDF SQEKPSTTYQ QPDSSYGACG GHKYQQNAEQ YGGTRDYWQG NGYWDPRSGR PPGTGVVYDR TQGQVPDSLT DDREEEENWD QQDGSHFSDQ SDKFLLSLQK DKGSVQAPEI SSNSIKDTLA VNEKKDFSKN LEKNDIKDRG PLKKRRQEIE SDSESDGELQ DRKKVRVE Positive Samples: Mouse brain, Rat brain; Cellular Location: Chromosome, Nucleus.

Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate. Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation. Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A. Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction. H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A. H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase. Required during angiogenesis. Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression.

Specifications

• Antigen: SETD2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Setd2
• Gene Alias: 4921524K10Rik; BC031601; FLJ16420; FLJ22472; FLJ23184; FLJ45883; HBP231; HIF1; HIF-1; HIP-1; histone-lysine N-methyltransferase SETD2; hSET2; HSPC069; huntingtin interacting protein 1; huntingtin yeast partner B; Huntingtin-interacting protein 1; Huntingtin-interacting protein B; HYPB; Kiaa1732; Kif9; kinesin family member 9; KMT3A; LLS; lysine N-methyltransferase 3A; p231HBP; Protein-lysine N-methyltransferase SETD2; SET domain containing 2; SET domain containing 2, histone lysine methyltransferase; SET domain-containing protein 2; SET2; Setd2
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 235626, 316013
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.54 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: E9Q5F9
• Gene Symbols: Setd2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1223-1430 of human SETD2 (NP_0548785).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Product Type: Antibody
• Isotype: IgG