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Invitrogen™ SETD6 Recombinant Rabbit Monoclonal Antibody (1Q1Z3)
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Catalog No. FEMA551377
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100 μL
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FEMA551377 100 μL
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Catalog No. FEMA551377 Supplier Invitrogen™ Supplier No. MA551377
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Description

Rabbit Recombinant Monoclonal Antibody

Immunogen sequence: TADIQMVTVR EAALQGTKTE AERHLVYERW DFLCKLEMVG EEGAFVIGRE EVLTEEELTT TLKVLCMPAE EFRELKDQDG GGDDKREEGS LTITNIPKLK ASWRQLLQNS VLLTLQTYAT DLKTDQGLLS NKEVYAKLSW REQQALQVRY GQKMILHQLL ELTS.

SETD6 (SET domain-containing protein 6) is a 473 amino acid protein that belongs to the SETD6 family. Containing one SET domain, SETD6 is structurally similar to the Rubisco large subunit methyltransferase. SETD6 is a proteinlysine N-methyltransferase that specifically monomethylates 'Lys-310' of the NFκB p65 subunit of NFκB complex, leading to down-regulate NFκB transcription factor activity. SETD6-mediated methylation renders NFκB p65 inert and attenuates NFκB p65-driven transcriptional programs, including inflammatory responses in primary immune cells. The SETD6-initiated lysine-methylation signaling cascade acts to restrain activation of NFκB-mediated inflammatory responses in diverse cell types.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SETD6
Applications ELISA, Western Blot
Classification Recombinant Monoclonal
Clone 1Q1Z3
Concentration 0.63 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene SETD6
Gene Accession No. D3ZSK5, Q8TBK2, Q9CWY3
Gene Alias 0610039J04Rik; 3110004G14Rik; AI413388; C76402; N-lysine methyltransferase SETD6; RGD1560538; SET domain containing 6; SET domain-containing protein 6; SETD6
Gene Symbols SETD6
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 310-473 of human SETD6 (NP_001153777.1).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 291844, 66083, 79918
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Format Liquid
Isotype IgG
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