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Invitrogen™ SETD7 Monoclonal Antibody (7C1B7E1), Invitrogen™

Catalog No. PIMA543500
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100 μL
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PIMA543500 50 μL
PIMA543017 100 μL
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Catalog No. PIMA543500 Supplier Invitrogen™ Supplier No. MA543500
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Description

Mouse Monoclonal Antibody

Specificity: Human SETD7/SET7/9

Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen SETD7
Applications ELISA
Classification Monoclonal
Clone 7C1B7E1
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene Setd7
Gene Accession No. Q8WTS6
Gene Alias 1600028F23Rik; FLJ21193; H3-K4 methyltransferase; H3-K4-HMTase; H3-K4-HMTase SETD7; H3K4MT; Histone H3-K4 methyltransferase SETD7; histone H3-lysine 4-specific methyltransferase; histone-lysine N-methyltransferase SETD7; Kiaa1717; KMT7; lysine N-methyltransferase 7; mKIAA1717; OTTHUMP00000220049; SET domain containing (lysine methyltransferase) 7; SET domain containing 7, histone lysine methyltransferase; SET domain containing 7, lysine methyltransferase; SET domain containing lysine methyltransferase 7; SET domain-containing protein 7; Set7; Set7/9; SET9; Setd7
Gene Symbols Setd7
Host Species Mouse
Immunogen Recombinant Human SETD7 protein.
Purification Method Protein A
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 80854
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2b
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