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  6. SETD7 Monoclonal Antibody (OTI2E3), TrueMAB™, OriGene 

SETD7 Monoclonal Antibody (OTI2E3), TrueMAB™, OriGene
SDP

Catalog No. 501674285
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50-167-4285 100 μL
50-254-0949 30 μL
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Catalog No. 50-167-4285 Supplier OriGene Supplier No. TA503377
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Description

Mouse Monoclonal Antibody

Histone methyltransferase that specifically monomethylates ′Lys-4′ of histone H3. H3 ′Lys-4′ methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates ′Lys-189′ of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates ′Lys-372′ of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Also able to demethylated ′Lys-372′ of p53/TP53 in vitro.

Specifications

Antigen SETD7
Applications Flow Cytometry, Western Blot
Classification Monoclonal
Clone OTI2E3
Concentration 0.31 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene SETD7
Gene Accession No. Q8VHL1, Q8WTS6
Gene Alias KMT7, SET7, SET7/9, SET9
Gene Symbols SETD7
Host Species Mouse
Immunogen Full length human recombit protein of human SETD7 produced in HEK293 cell.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 73251, 80854
Target Species Human, Mouse
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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