SETD7 Monoclonal Antibody (OTI5B11), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA503354

Catalog No. 50-167-4270

Description

Histone methyltransferase that specifically monomethylates ′Lys-4′ of histone H3. H3 ′Lys-4′ methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates ′Lys-189′ of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates ′Lys-372′ of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Also able to demethylated ′Lys-372′ of p53/TP53 in vitro.

Specifications

• Antigen: SETD7
• Classification: Monoclonal
• Concentration: 0.25 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q8WTS6
• Gene Symbols: SETD7
• Immunogen: Full length human recombit protein of human SETD7 produced in HEK293T cell.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Flow Cytometry, Western Blot
• Clone: OTI5B11
• Conjugate: Unconjugated
• Gene: SETD7
• Gene Alias: KMT7, SET7, SET7/9, SET9
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 80854
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid