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SETD7 Monoclonal Antibody (OTI5B11), TrueMAB™, OriGene
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene TA503354

Encompass_Preferred

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Catalog No. 50-167-4270


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Description

Description

Histone methyltransferase that specifically monomethylates ′Lys-4′ of histone H3. H3 ′Lys-4′ methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates ′Lys-189′ of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates ′Lys-372′ of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Also able to demethylated ′Lys-372′ of p53/TP53 in vitro.
Specifications

Specifications

SETD7
Monoclonal
0.25 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Q8WTS6
SETD7
Full length human recombit protein of human SETD7 produced in HEK293T cell.
100 μL
Primary
Human
Antibody
IgG2a
Flow Cytometry, Western Blot
OTI5B11
Unconjugated
SETD7
KMT7, SET7, SET7/9, SET9
Mouse
Affinity Chromatography
RUO
80854
-20° C, Avoid Freeze/Thaw Cycles
Liquid
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