SETD7 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Supplier:  Proteintech Group Inc 248401AP150UL

Catalog No. 50-173-4572

Description

Histone methyltransferase that specifically monomethylates ′Lys-4′ of histone H3. H3 ′Lys-4′ methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates ′Lys-189′ of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates ′Lys-372′ of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Also able to demethylated ′Lys-372′ of p53/TP53 in vitro.

Specifications

• Antigen: SETD7
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SETD7
• Gene Alias: H3 K4 HMTase SETD7, KIAA1717, KMT7, Lysine N methyltransferase 7, SET7, SET7/9, SET9, SETD7
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 689954, 73251, 80854
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunocytochemistry, Immunofluorescence, Western Blot
• Concentration: 0.41 mg/mL
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Accession No.: Q8VHL1, Q8WTS6
• Gene Symbols: Setd7
• Immunogen: SETD7 Fusion Protein Ag18219
• Quantity: 150 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG