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  6. SETD7 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech 

SETD7 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
SDP

Catalog No. 501734572 Shop All Proteintech Group Inc Products
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50-173-4572 150 μL
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Catalog No. 50-173-4572 Supplier Proteintech Group Inc Supplier No. 248401AP150UL
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Description

Rabbit Polyclonal Antibody

Histone methyltransferase that specifically monomethylates ′Lys-4′ of histone H3. H3 ′Lys-4′ methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates ′Lys-189′ of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates ′Lys-372′ of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Also able to demethylated ′Lys-372′ of p53/TP53 in vitro.

Specifications

Antigen SETD7
Applications Immunocytochemistry, Immunofluorescence, Western Blot
Classification Polyclonal
Concentration 0.41 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene SETD7
Gene Accession No. Q8VHL1, Q8WTS6
Gene Alias H3 K4 HMTase SETD7, KIAA1717, KMT7, Lysine N methyltransferase 7, SET7, SET7/9, SET9, SETD7
Gene Symbols Setd7
Host Species Rabbit
Immunogen SETD7 Fusion Protein Ag18219
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 689954, 73251, 80854
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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