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SETD7 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 248401AP

Catalog No. 50-173-4572


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Description

Description

Histone methyltransferase that specifically monomethylates  ft.Lys-4 ft. of histone H3. H3  ft.Lys-4 ft. methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates  ft.Lys-189 ft. of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates  ft.Lys-372 ft. of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Also able to demethylated  ft.Lys-372 ft. of p53/TP53 in vitro.
Specifications

Specifications

SETD7
0.41 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q8VHL1, Q8WTS6
H3 K4 HMTase SETD7, KIAA1717, KMT7, Lysine N methyltransferase 7, SET7, SET7/9, SET9, SETD7
Rabbit
IgG
150 μL
-20°C
Primary
689954, 73251, 80854
Immunocytochemistry, Immunofluorescence, Western Blot
Unconjugated
SETD7
Liquid
Setd7
SETD7 Fusion Protein Ag18219
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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