Invitrogen™ SF1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA553871

Catalog No. PIPA553871

Description

Immunogen sequence: NQDTMEQKTV IPGMPTVIPP GLTREQERAY IVQLQIEDLT RKLRTGDLGI PPNPEDRSPS PEPIYNSEGK RLNTREFRTR KKLEEERHNL ITEMVALNPD FKPPADYKPP ATRVSDKVMI PQDEYPEINF VGLLI Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 99%.

Splicing factor 1 is a nuclear pre-mRNA splicing factor. The protein specifically recognizes the intron branch point sequence at the 3' splice site, together with the large subunit of U2 auxiliary factor (U2AF), and is required for the early stages of spliceosome assembly. It also plays a role in nuclear pre-mRNA retention and transcriptional repression. The protein contains an N-terminal U2AF ligand motif, a central hnRNP K homology motif and quaking 2 region which bind a key branch-site adenosine within the branch point sequence, a zinc knuckles domain, and a C-terminal proline-rich domain. Alternative splicing results in multiple transcript variants.

Specifications

• Antigen: SF1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SF1
• Gene Alias: BBP; D11S636; M ZFM1; Mammalian branch point-binding protein; MBBP; MZFM; SF; SF1; Splicing factor 1; transcription factor ZFM1; WBP4; wu:fc09f06; ZCCHC25; ZFM1; Zfp162; Zinc finger gene in MEN1 locus; zinc finger protein 162; ZNF162
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 7536
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q15637
• Gene Symbols: SF1
• Immunogen: Recombinant protein corresponding to Human SF1. Recombinant protein control fragment (Product #RP-100742).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG