SF3A1 Monoclonal Antibody (OTI1B5), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA800496

Catalog No. 50-167-8372

Description

This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family; named for the SURP motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms.

Specifications

• Antigen: SF3A1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q15459
• Gene Symbols: SF3A1
• Immunogen: Human recombit protein fragment corresponding to amino acids 249-568 of human SF3A1 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: OTI1B5
• Conjugate: Unconjugated
• Gene: SF3A1
• Gene Alias: PRP21, PRPF21, SAP114, SF3A120
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10291
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid