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SF3A1 Monoclonal Antibody (OTI1B5), TrueMAB™, OriGene

Mouse Monoclonal Antibody
Supplier: OriGene TA800496

Description
This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family; named for the SURP motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms.Specifications
SF3A1 | |
Monoclonal | |
1 mg/mL | |
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide | |
Q15459 | |
SF3A1 | |
Human recombit protein fragment corresponding to amino acids 249-568 of human SF3A1 produced in E.coli. | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG1 |
Western Blot | |
OTI1B5 | |
Unconjugated | |
SF3A1 | |
PRP21, PRPF21, SAP114, SF3A120 | |
Mouse | |
Affinity Chromatography | |
RUO | |
10291 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Liquid |
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