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Invitrogen™ SF3A1 Monoclonal Antibody (OTI3F4)
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA526472
Description
SF3A1 Monoclonal Antibody for Western Blot, IHC (P)
This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family; named for the SURP motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms.
Specifications
SF3A1 | |
Monoclonal | |
1 mg/mL | |
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3 | |
Q15459 | |
Sf3a1 | |
Human recombinant protein fragment corresponding to amino acids 249-568 of SF3A1 produced in E.coli. | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG2a |
Immunohistochemistry (Paraffin), Western Blot | |
OTI3F4 | |
Unconjugated | |
Sf3a1 | |
1200014H24Rik; 5930416L09Rik; AI159724; pre-mRNA processing 21; pre-mRNA splicing factor SF3a (120 kDa subunit); PRP21; PRPF21; SAP 114; SAP114; Sf3a1; sf3a1 protein; SF3A120; si:dz150f13.2; spliceosome-associated protein 114; splicing factor 3 subunit 1; splicing factor 3A subunit 1; splicing factor 3a, subunit 1; splicing factor 3a, subunit 1, 120kD; splicing factor 3a, subunit 1, 120kDa; Unknown (protein for MGC:65786); wu:fc38e01; wu:fc50a11; wu:fj37c05; zgc:65786 | |
Mouse | |
Affinity chromatography | |
RUO | |
10291 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid |
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