Invitrogen™ SF3A1 Monoclonal Antibody (OTI3F4)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA526472

Catalog No. PIMA526472

Description

SF3A1 Monoclonal Antibody for Western Blot, IHC (P)

This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family; named for the SURP motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms.

Specifications

• Antigen: SF3A1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q15459
• Gene Symbols: Sf3a1
• Immunogen: Human recombinant protein fragment corresponding to amino acids 249-568 of SF3A1 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI3F4
• Conjugate: Unconjugated
• Gene: Sf3a1
• Gene Alias: 1200014H24Rik; 5930416L09Rik; AI159724; pre-mRNA processing 21; pre-mRNA splicing factor SF3a (120 kDa subunit); PRP21; PRPF21; SAP 114; SAP114; Sf3a1; sf3a1 protein; SF3A120; si:dz150f13.2; spliceosome-associated protein 114; splicing factor 3 subunit 1; splicing factor 3A subunit 1; splicing factor 3a, subunit 1; splicing factor 3a, subunit 1, 120kD; splicing factor 3a, subunit 1, 120kDa; Unknown (protein for MGC:65786); wu:fc38e01; wu:fc50a11; wu:fj37c05; zgc:65786
• Host Species: Mouse
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10291
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid