SF3A1 Mouse anti-Human, Clone: OTI1F10, lyophilized, TrueMAB™

Catalog No.	Quantity
50-166-5107	100 μg

Catalog No. 50-166-5107 Supplier OriGene Supplier No. CF800462

Description

Mouse Monoclonal Antibody

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family; named for the SURP motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms.

Specifications

• Antigen: SF3A1
• Applications: Western Blot
• Classification: Monoclonal
• Clone: OTI1F10
• Conjugate: Unconjugated
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene: SF3A1
• Gene Accession No.: Q15459
• Gene Alias: PRP21, PRPF21, SAP114, SF3A120
• Gene Symbols: SF3A1
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 249-568 of human SF3A1 produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 10291
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG1