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Invitrogen™ SF3A1 Polyclonal Antibody
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Catalog No. PIPA556334
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100 μL
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PIPA556334 100 μL
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Catalog No. PIPA556334 Supplier Invitrogen™ Supplier No. PA556334
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: YPPPEVRNIV DKTASFVARN GPEFEARIRQ NEINNPKFNF LNPNDPYHAY YRHKVSEFKE GKAQEPSAAI PKVMQQQQQT TQQQLPQKVQ AQVIQETIVP KEPPPEFEFI ADPPSISAFD LDVVKLTAQF VARNGRQFLT QLMQKEQRNY QFDFLRPQHS LFNYFTKLVE QYTKI Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 99%.

This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family; named for the SURP motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SF3A1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Sf3a1
Gene Accession No. Q15459
Gene Alias 1200014H24Rik; 5930416L09Rik; AI159724; pre-mRNA processing 21; pre-mRNA splicing factor SF3a (120 kDa subunit); PRP21; PRPF21; SAP 114; SAP114; Sf3a1; sf3a1 protein; SF3A120; si:dz150f13.2; spliceosome-associated protein 114; splicing factor 3 subunit 1; splicing factor 3A subunit 1; splicing factor 3a, subunit 1; splicing factor 3a, subunit 1, 120kD; splicing factor 3a, subunit 1, 120kDa; Unknown (protein for MGC:65786); wu:fc38e01; wu:fc50a11; wu:fj37c05; zgc:65786
Gene Symbols Sf3a1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human SF3A1. Recombinant protein control fragment (Product #RP-91383).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10291
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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