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SF3B2 Rabbit anti-Human, Polyclonal, Proteintech
SDP

Catalog No. 501726713 Shop All Proteintech Group Inc Products
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50-172-6713 150 μL
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Catalog No. 50-172-6713 Supplier Proteintech Group Inc Supplier No. 109191AP150UL
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Description

Rabbit Polyclonal Antibody

SF3b is a U2 snRNP-associated protein complex essential for spliceosome assembly. SF3b contains the spliceosomal proteins SAP 49, SAP 130, SAP 145, and SAP 155. SAP 130, SAP 145, and SAP 155 are present in a protein complex in HeLa nuclear extracts and associate with one another. While SAP 155 and SAP 130 interact with each other (directly or indirectly) within this complex, SAP 49 and SAP 145 are known to interact directly with each other. Unexpectedly, the SAP 49-SAP 145 protein-protein interaction requires the amino-terminus of SAP 49, which contains two RNA-recognition motifs. The observation that SAP 49 and SAP 145 interact directly with both U2 snRNP and the pre-mRNA suggests that this protein complex plays a role in tethering U2 snRNP to the branch site.

Specifications

Antigen SF3B2
Applications Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.37 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene SF3B2
Gene Accession No. Q13435
Gene Alias SAP 145, SAP145, SF3B145, SF3b150, SF3B2, Splicing factor 3B subunit 2
Gene Symbols SF3B2
Host Species Rabbit
Immunogen SF3B2 Fusion Protein Ag1009
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10992
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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