Invitrogen™ SFRP4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA562219

Catalog No. PIPA562219

Description

Immunogen sequence: PTLATYLSKN YSYVIHAKIK AVQRSGCNEV TTVVDVKEIF KSSSPIPRTQ VPLITNSSCQ CPHILPHQDV LIMCYEWRSR MMLLENCLVE KWRDQLSKRS IQWEERLQEQ RRTVQDKKKT AGRTSRSNPP KPKGKPPAPK PASPK Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 92%.

Secreted Frizzled-Related Proteins (sFRPs) are a family of glycosylated Wnt antagonists characterized by a conserved cysteine-rich domain that shares homology with the cysteine-rich, extracellular domain Frizzled proteins use for the binding of Wnt proteins and receptors. Lacking the transmembrane and intracellular domains of the Frizzled proteins, sFRPs function as soluble modulators of the Wnt signaling pathway through the direct binding of Wnt proteins to this cysteine-rich domain, and the resultant inhibition of Wnt receptor binding and signaling capabilities. sFRP-4 is widely distributed in a variety of embryonic and adult tissues where it can function as a circulating antiangiogenic factor, a potent proapoptotic factor, an inhibitor of insulin secretion, and a suppressor of both tumor growth and metastatic potential through disruption of the Wnt signaling pathway. Research has demonstrated the existence of a direct correlation between the downregulation and/or absence of circulating sFRP-4 and the progression of several cancer types, including ovarian, endometrial, prostate and lung. Upregulation of circulating sFRP-4 has been linked to the deterioration of glucose metabolism in the case of type 2 diabetes, as well as the suppression of the keratinocyte hyperproliferation and epidermal hyperlasia that are definitive of psoriasis.

Specifications

• Antigen: SFRP4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SFRP4
• Gene Alias: Ddc4; DDC-4 protein; Frizzled protein, human endometrium; frizzled related protein; frizzled-related protein; frizzled-related protein 4; FRP; FRP-4; FRPHE; MGC26498; secreted frizzled related protein 4; secreted frizzled-related protein 4; secreted frizzled-related protein 4; secreted frizzled-related protein 4; secreted frizzled-related sequence protein 4; Sfrp4; sFRP-4
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6424
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q6FHJ7
• Gene Symbols: SFRP4
• Immunogen: Recombinant protein corresponding to Human SFRP4. Recombinant protein control fragment (Product #RP-103081).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov