Invitrogen™ SFTPB Polyclonal Antibody

Chicken Polyclonal Antibody

Supplier:  Invitrogen™ SA172016

Catalog No. SA172016

Description

SA1-72016 detects Surfactant Protein B in human, mouse, and rat samples. SA1-72016 has been successfully used in western blot procedures. The SA1-72016 immunogen is from Chicken immunized with SP-B purified from Infasurf.

Pulmonary surfactant is a complex mixture of phospholipids and proteins that is secreted from type II cells in alveoli and reduces the surface tension at the alveolar air-liquid interface, providing alveolar stability necessary for normal ventilation. Four distinct proteins isolated from pulmonary surfactant are termed surfactant proteins A, B, C, and D. SP-A (28-36kDa) and SP-D (43kDa) are collagenous carbohydrate-binding proteins, whereas SP-B (8-9kDa) and SP-C (4kDa) are non-collagenous hydrophobic proteins. SP-B is expressed in pulmonary adenocarcinomas with acinar, papillary, bronchioloalveolar, and solid growth patterns. Squamous cell and large cell carcinomas of the lung and nonpulmonary adenocarcinomas do not express SP-B. ProSP-B is glycosylated in the Golgi apparatus and undergoes carboxy- and amino-terminal proteolysis by a cathepsin D-like protease.

Specifications

• Antigen: SFTPB
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SFTPB
• Gene Alias: 18 kDa pulmonary-surfactant protein; 6 kDa protein; AI562151; P SFTB3; pot. surfactant-associated protein precursor; putative; preproprotein; PSP-B; Pulmonary surfactant protein 18; pulmonary surfactant protein B; pulmonary surfactant-associated protein B; pulmonary surfactant-associated protein B precursor; pulmonary surfactant-associated protein B; LOW QUALITY PROTEIN: pulmonary surfactant-associated protein B; Pulmonary surfactant-associated proteolipid SPL(Phe); SF-B; SFPB; SFTB3; SFTP3; Sftp-3; Sftpb; SMDP1; SP 18; SP-B; SPBS; surfactant associated protein B; surfactant protein B; surfactant protein-B; surfactant pulmonary-associated protein B; surfactant, pulmonary-associated protein B
• Host Species: Chicken
• Purification Method: IgY fraction
• Regulatory Status: RUO
• Gene ID (Entrez): 507398
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 20 mg/mL
• Formulation: PBS with 0.075% sodium azide; pH 7.2
• Gene Accession No.: P15781
• Gene Symbols: SFTPB
• Immunogen: SP-B purified from Infasurf.
• Quantity: 10 mg
• Primary or Secondary: Primary
• Target Species: Bovine
• Product Type: Antibody
• Isotype: IgY