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SFTPB Precursor Monoclonal Antibody (SPB01 (1-2-A5-9)), Invitrogen™

Catalog No. PIMA513975
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500 μL
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PIMA513975 500 μL
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Catalog No. PIMA513975 Supplier Thermo Scientific Supplier No. MA513975
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Description

Mouse Monoclonal Antibody

MA5-13975 targets Surfactant Protein B (Precursor) in IF and IHC (P) applications and shows reactivity with Human and Rat samples. The MA5-13975 immunogen is recombinant pro-surfactant protein B.

Pulmonary surfactant is a complex mixture of phospholipids and proteins that is secreted from type II cells in alveoli and reduces the surface tension at the alveolar air-liquid interface, providing alveolar stability necessary for normal ventillation. Four distinct proteins isolated from pulmonary surfactant are termed surfactant proteins A, B, C, and D. SP-A (28-36kDa) and SP-D (43kDa) are collagenous carbohydrate-binding proteins, whereas SP-B (8-9kDa) and SP-C (4kDa) are non-collagenous hydrophobic proteins. SP-B is expressed in pulmonary adenocarcinomas with acinar, papillary, bronchioloalveolar, and solid growth patterns. Squamous cell and large cell carcinomas of the lung and nonpulmonary adenocarcinomas do not express SP-B. ProSP-B is glycosylated in the Golgi apparatus and undergoes carboxy- and amino-terminal proteolysis by a cathepsin D-like protease.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SFTPB Precursor
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone SPB01 (1-2-A5-9)
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
Gene SFTPB
Gene Accession No. P07988, P22355
Gene Alias 18 kDa pulmonary-surfactant protein; 6 kDa protein; PSP-B; Pulmonary surfactant-associated protein B; pulmonary surfactant-associated proteolipid SPL(Phe); SFTB3; SFTP3; SFTPB; SMDP1; SP-B; surfactant associated protein B; surfactant protein B; surfactant pulmonary-associated protein B; surfactant, pulmonary-associated protein B
Gene Symbols SFTPB
Host Species Mouse
Immunogen Recombinant pro-surfactant protein B
Purification Method Protein A
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 192155, 6439
Target Species Human, Rat
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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