Invitrogen™ SFTPB Precursor Recombinant Rabbit Monoclonal Antibody (RM370)

Catalog No.	Quantity
PIMA533047	100 μL

Catalog No. PIMA533047 Supplier Invitrogen™ Supplier No. MA533047

Description

Rabbit Recombinant Monoclonal Antibody

Specificity: reacts to human SP-B (Surfactant protein B) and proSP-B. Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Pulmonary surfactant is a complex mixture of phospholipids and proteins that is secreted from type II cells in alveoli and reduces the surface tension at the alveolar air-liquid interface, providing alveolar stability necessary for normal ventillation. Four distinct proteins isolated from pulmonary surfactant are termed surfactant proteins A, B, C, and D. SP-A (28-36kDa) and SP-D (43kDa) are collagenous carbohydrate-binding proteins, whereas SP-B (8-9kDa) and SP-C (4kDa) are non-collagenous hydrophobic proteins. SP-B is expressed in pulmonary adenocarcinomas with acinar, papillary, bronchioloalveolar, and solid growth patterns. Squamous cell and large cell carcinomas of the lung and nonpulmonary adenocarcinomas do not express SP-B. ProSP-B is glycosylated in the Golgi apparatus and undergoes carboxy- and amino-terminal proteolysis by a cathepsin D-like protease.

Specifications

• Antigen: SFTPB Precursor
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Recombinant Monoclonal
• Clone: RM370
• Concentration: 0.05 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
• Gene: SFTPB
• Gene Accession No.: P07988
• Gene Alias: 18 kDa pulmonary-surfactant protein; 6 kDa protein; PSP-B; Pulmonary surfactant-associated protein B; pulmonary surfactant-associated proteolipid SPL(Phe); SFTB3; SFTP3; SFTPB; SMDP1; SP-B; surfactant associated protein B; surfactant protein B; surfactant pulmonary-associated protein B; surfactant, pulmonary-associated protein B
• Gene Symbols: SFTPB
• Host Species: Rabbit
• Immunogen: A peptide corresponding to residues near the C-terminus of human SP-B (Surfactant protein B).
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 6439
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG