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Invitrogen™ SFXN4 Polyclonal Antibody
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Catalog No. PIPA554270
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100 μL
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PIPA554270 100 μL
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Catalog No. PIPA554270 Supplier Invitrogen™ Supplier No. PA554270
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: KYGLTGPWIK RLLPVIFLVQ ASGMNVYMSR SLESIKGIAV MDKEGNVLGH SRIAGTKAVR ET Highest antigen sequence identity to the following orthologs: Mouse - 60%, Rat - 63%.

Sideroflexin 4 (SFXN4) is a gene primarily associated with mitochondrial functionality and disease. It encodes a protein that is crucial for the assembly of complex I within mitochondria, a critical component of the electron transport chain. Mutations in SFXN4 can result in mitochondrial diseases due to its pivotal role in this process. Interestingly, SFXN4 belongs to the sideroflexin family, traditionally known for amino acid transport, indicating a functional evolution to support mitochondrial assembly. In the context of cancer, specifically ovarian cancer, SFXN4 is involved in the synthesis of iron-sulfur clusters (Fe-S), which are essential for cell growth and division. Inhibition of SFXN4 disrupts Fe-S biogenesis, highlighting its potential as a target for anti-cancer therapy. Additionally, SFXN4's expression and function have been correlated with immune pathways in hepatocellular carcinoma, suggesting broader implications in cancer biology. Knockdown studies and natural mutations demonstrate SFXN4's role in mitochondrial diseases, including macrocytic anemia observed in zebrafish models and implications in human mitochondriopathy.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SFXN4
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene SFXN4
Gene Accession No. Q6P4A7
Gene Alias BCRM1; Breast cancer resistance marker 1; COXPD18; SFXN4; sideroflexin 4; sideroflexin-4
Gene Symbols SFXN4
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human SFXN4. Recombinant protein control fragment (Product #RP-91190).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 119559
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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