Invitrogen™ SFXN4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA554270

Catalog No. PIPA554270

Description

Immunogen sequence: KYGLTGPWIK RLLPVIFLVQ ASGMNVYMSR SLESIKGIAV MDKEGNVLGH SRIAGTKAVR ET Highest antigen sequence identity to the following orthologs: Mouse - 60%, Rat - 63%.

Sideroflexin 4 (SFXN4) is a gene primarily associated with mitochondrial functionality and disease. It encodes a protein that is crucial for the assembly of complex I within mitochondria, a critical component of the electron transport chain. Mutations in SFXN4 can result in mitochondrial diseases due to its pivotal role in this process. Interestingly, SFXN4 belongs to the sideroflexin family, traditionally known for amino acid transport, indicating a functional evolution to support mitochondrial assembly. In the context of cancer, specifically ovarian cancer, SFXN4 is involved in the synthesis of iron-sulfur clusters (Fe-S), which are essential for cell growth and division. Inhibition of SFXN4 disrupts Fe-S biogenesis, highlighting its potential as a target for anti-cancer therapy. Additionally, SFXN4's expression and function have been correlated with immune pathways in hepatocellular carcinoma, suggesting broader implications in cancer biology. Knockdown studies and natural mutations demonstrate SFXN4's role in mitochondrial diseases, including macrocytic anemia observed in zebrafish models and implications in human mitochondriopathy.

Specifications

• Antigen: SFXN4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SFXN4
• Gene Alias: BCRM1; Breast cancer resistance marker 1; COXPD18; SFXN4; sideroflexin 4; sideroflexin-4
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 119559
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.4 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q6P4A7
• Gene Symbols: SFXN4
• Immunogen: Recombinant protein corresponding to Human SFXN4. Recombinant protein control fragment (Product #RP-91190).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG