Tocris™ SGC 0946

Highly potent and selective DOT1L inhibitor; cell permeable

Supplier:  Tocris™ 4541/2

Catalog No. 45-412

Description

SGC 0946 is a highly potent DOT1L methyltransferase inhibitor (Kd = 0.06 nM, IC50 = 0.3 nM in a radioactive assay); blocks H3K79 methylation in A431 cells and MCF10A cells. Inactive at 12 histone methyltransferases and DNMT1. Selectively kills cells transformed with the MLL-AF9 fusion oncogene in an in vitro model of leukemia; lowers levels of MLL target genes HOXA9 and Meis1.

To request the negative control for SGC0946, please fill out the SGC0649 request form on the SGC website.

Specifications

• Chemical Name or Material: 1-[3-[[[(2 R,3 S,4 R,5 R)-5-(4-Amino-5-bromo-7 H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl](isopropyl)amino]propyl]-3-[4-(2,2-dimethylethyl)phenyl]urea
• Quantity: 2 mg
• Molecular Formula: C₂₈H₄₀BrN₇O₄

• CAS: 1561178-17-3
• Target: Lysine Methyltransferase Inhibitors
• Purity: 99%

Safety and Handling

Recommended Storage : Store at -20°C