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Tocris Bioscience™ SGC 0946
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Catalog No. 45412
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Quantity:
2 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Highly potent and selective DOT1L inhibitor; cell permeable

SGC 0946 is a highly potent DOT1L methyltransferase inhibitor (Kd = 0.06 nM, IC50 = 0.3 nM in a radioactive assay); blocks H3K79 methylation in A431 cells and MCF10A cells. Inactive at 12 histone methyltransferases and DNMT1. Selectively kills cells transformed with the MLL-AF9 fusion oncogene in an in vitro model of leukemia; lowers levels of MLL target genes HOXA9 and Meis1.

To request the negative control for SGC0946, please fill out the SGC0649 request form on the SGC website.

Specifications

Chemical Name or Material 1-[3-[[[(2 R,3 S,4 R,5 R)-5-(4-Amino-5-bromo-7 H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl](isopropyl)amino]propyl]-3-[4-(2,2-dimethylethyl)phenyl]urea
CAS 1561178-17-3
Quantity 2 mg
Target Lysine Methyltransferase Inhibitors
Molecular Formula C28H40BrN7O4
Purity 99%
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