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  5. Tocris Bioscience™ SGC SMARCA-BRDVIII

Tocris Bioscience™ SGC SMARCA-BRDVIII
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Catalog No. 746050
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74-605-0 50 mg
74-601-0 10 mg
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Catalog No. 74-605-0 Supplier Tocris Bioscience™ Supplier No. 7460/50
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Description

Potent and selective SMARCA2/4 and PB1(bromo 5)-selective SWI/SNF bromodomain inhibitor

SGC-SMARCA-BRDVIII is a selective and high affinity SMARCA2/4 and PB1(bromo 5)-selective SWI/SNF bromodomains (Kd(ITC) values are 35, 36 and 13 nM, respectively). SGC-SMARCA-BRDVIII exhibits selectivity over 25 other bromodomain families and shows no off-target activity on 85 protein kinases screened using temperature-shift binding assays. SGC-SMARCA-BRDVIII suppresses formation of 3T3-L1 mouse fibroblasts into adipocytes (EC50 <1.0 μM).

Specifications

Chemical Name or Material 1,1-Dimethylethyl 4-[3-amino-6-(2-hydroxyphenyl)-4-pyridazinyl]-1-piperazinecarboxylate bromodomains
CAS 1997319-84-2
Quantity 50 mg
Target Bromodomain Inhibitors
Molecular Formula C19H25N5O3
Purity 0.98
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