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  5. R&D Systems™ SGC UBD253

R&D Systems™ SGC UBD253
SDP

Catalog No. RD10193528 Shop All Novus Products
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RD10193528 50 mg
RD10193526 10 mg
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Catalog No. RD10193528 Supplier R&D Systems™ Supplier No. 8074/50

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Description

A Tocris product, part of R&D Systems.

SGC UBD253 is a potent and selective histone deacetylase 6 (HDAC6-UBD) antagonist (KD = 80 nM, 84 nM and 95 nM determined by ITC, SPR and FP, respectively, for the UBD domain; KD = 0.26 μM and 0.44 μM determined by SPR and FP, respectively, for full length HDAC6). Displays 50-fold selectivity for HDAC6 over other UBD proteins, with the exception of USP16 (15-fold). In live cells, it significantly decreases the interaction between HDAC6 and ISG15 (EC50 = 1.9 μM in a NanoBRET assay). Treatment with SGC UBD253 does not inhibit the catalyitic activity of HDAC6.

Specifications

Chemical Name or Material 3-(8-Chloro-3-(2-((2-methoxybenzyl)amino)-2-oxoethyl)-4-oxo-3,4-dihydroquinazolin-2-yl)propanoic acid
CAS 3033200-03-9
Quantity 50 mg
Product Line Tocris
Target Class II Histone Deacetylases Inhibitors
Molecular Formula C21H20ClN3O5
Purity 98%
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