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Invitrogen™ SH3YL1 Polyclonal Antibody
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Catalog No. PIPA531797
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100 μL
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PIPA531797 100 μL
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Catalog No. PIPA531797 Supplier Invitrogen™ Supplier No. PA531797
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: NT2D1, PC-3, U87-MG, SK-N-SH. Predicted reactivity: Mouse (88%), Rat (89%), Pig (91%), Chimpanzee (99%), Bovine (90%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The SH3YL1 gene encodes a protein that contains an SH3 domain and is involved in various signaling pathways. It is particularly significant in the context of androgen receptor (AR) signaling, where it acts as a coregulator for AR target genes. Studies have shown that SH3YL1 is essential for the transcriptional activation of genes modulated by the AR, and its dysregulation is associated with aggressive prostate cancer. Additionally, elevated plasma levels of SH3YL1 have been identified as a biomarker for diabetic nephropathy, indicating its broader role in human health and disease. SH3YL1 protein expression is particularly noted in the kidneys of diabetic patients, suggesting its involvement in the development of diabetic complications.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SH3YL1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.76 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene SH3YL1
Gene Accession No. Q96HL8
Gene Alias RAY; SH3 and SYLF domain containing 1; SH3 domain containing, Ysc84-like 1; SH3 domain-containing YSC84-like protein 1; SH3YL1
Gene Symbols SH3YL1
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human SH3YL1. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26751
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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