Invitrogen™ SHANK1 Monoclonal Antibody (N22/21), APC

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA545446

Catalog No. PIMA545446

Description

1 μg/mL of MA5-45446 was sufficient for detection of Shank1 in 10 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 190-220 kDa (alternative splice variants). No cross-reactivity against Shank2 or Shank3.

Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.

Specifications

• Antigen: SHANK1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: 2.48mM MES, 95.64mM phosphate with 0.5M EDTA and no preservative; pH 7.4
• Gene Accession No.: D3YZU1, Q9WV48, Q9Y566
• Gene Symbols: SHANK1
• Immunogen: Fusion protein amino acids 469-691 (SH3/PDZ domains) of rat Shank1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry, Microarray
• Clone: N22/21
• Conjugate: APC
• Gene: SHANK1
• Gene Alias: GKAP/SAPAP interacting protein; GKAP/SAPAP-interacting protein; OTTHUMP00000174437; SAPAP-interacting protein synamon; SH3 and multiple ankyrin repeat domains 1; SH3 and multiple ankyrin repeat domains protein 1; SH3/ankyrin domain gene 1; SHANK 1; Shank1; Shank1a; somatostatin receptor-interacting protein; SPANK 1; Spank1; SPANK-1; SSTR-interacting protein; Sstrip; Synamon
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 243961, 50944, 78957
• Content And Storage: 4°C
• Form: Liquid

Safety and Handling

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