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Invitrogen™ SHANK1 Monoclonal Antibody (N22/21), FITC
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Catalog No. PIMA545447
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100 μg
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PIMA545447 100 μg
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Catalog No. PIMA545447 Supplier Invitrogen™ Supplier No. MA545447
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Description

Mouse Monoclonal Antibody

1 μg/mL of MA5-45447 was sufficient for detection of Shank1 in 10 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 190-220 kDa (alternative splice variants). No cross-reactivity against Shank2 or Shank3.

Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SHANK1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry, Microarray
Classification Monoclonal
Clone N22/21
Concentration 1 mg/mL
Conjugate FITC
Formulation PBS, 9.1mM sodium bicarbonate with 640.91mM DMSO, 136.36mM ethanolamine and no preservative; pH 7.4
Gene SHANK1
Gene Accession No. D3YZU1, Q9WV48, Q9Y566
Gene Alias GKAP/SAPAP interacting protein; GKAP/SAPAP-interacting protein; OTTHUMP00000174437; SAPAP-interacting protein synamon; SH3 and multiple ankyrin repeat domains 1; SH3 and multiple ankyrin repeat domains protein 1; SH3/ankyrin domain gene 1; SHANK 1; Shank1; Shank1a; somatostatin receptor-interacting protein; SPANK 1; Spank1; SPANK-1; SSTR-interacting protein; Sstrip; Synamon
Gene Symbols SHANK1
Host Species Mouse
Immunogen Fusion protein amino acids 469-691 (SH3/PDZ domains) of rat Shank1.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 243961, 50944, 78957
Target Species Human, Mouse, Rat
Content And Storage 4°C, store in dark
Product Type Antibody
Form Liquid
Isotype IgG1
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Safety and Handling

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