Invitrogen™ SHANK1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA14180

Catalog No. PA14180

Description

PA1-4180 detects SHANK1a in human, rat, and mouse samples. PA1-4180 has been successfully used in Western blot, immunofluorescence, and immunofluoresence procedures. By Western blot this antibody detects a ~212 kDa protein representing SHANK1a in rat brain lysate. The PA1-4180 immunogen is a synthetic peptide corresponding to the C-terminal residues S(1951) G P I Y P G L F D I R S S(1964) of rat Shank1a. Maintain at 4ºC for 3 months or at -20ºC for longer periods. Avoid freeze/thaw cycles.

Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.

Specifications

• Antigen: SHANK1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SHANK1
• Gene Alias: GKAP/SAPAP interacting protein; GKAP/SAPAP-interacting protein; OTTHUMP00000174437; SAPAP-interacting protein synamon; SH3 and multiple ankyrin repeat domains 1; SH3 and multiple ankyrin repeat domains protein 1; SH3/ankyrin domain gene 1; SHANK 1; Shank1; Shank1a; somatostatin receptor-interacting protein; SPANK 1; Spank1; SPANK-1; SSTR-interacting protein; Sstrip; Synamon
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 243961, 50944, 78957
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: D3YZU1, Q9WV48, Q9Y566
• Gene Symbols: SHANK1
• Immunogen: Synthetic peptide corresponding to the C-terminal residues S(1951) G P I Y P G L F D I R S S(1964) of rat Shank1a.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG