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Invitrogen™ SHANK1 Polyclonal Antibody
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Catalog No. PA14180
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100 μg
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Catalog No. Quantity
PA14180 100 μg
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Catalog No. PA14180 Supplier Invitrogen™ Supplier No. PA14180
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Description

Rabbit Polyclonal Antibody

PA1-4180 detects SHANK1a in human, rat, and mouse samples. PA1-4180 has been successfully used in Western blot, immunofluorescence, and immunofluoresence procedures. By Western blot this antibody detects a ~212 kDa protein representing SHANK1a in rat brain lysate. The PA1-4180 immunogen is a synthetic peptide corresponding to the C-terminal residues S(1951) G P I Y P G L F D I R S S(1964) of rat Shank1a. Maintain at 4ºC for 3 months or at -20ºC for longer periods. Avoid freeze/thaw cycles.

Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SHANK1
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene SHANK1
Gene Accession No. D3YZU1, Q9WV48, Q9Y566
Gene Alias GKAP/SAPAP interacting protein; GKAP/SAPAP-interacting protein; OTTHUMP00000174437; SAPAP-interacting protein synamon; SH3 and multiple ankyrin repeat domains 1; SH3 and multiple ankyrin repeat domains protein 1; SH3/ankyrin domain gene 1; SHANK 1; Shank1; Shank1a; somatostatin receptor-interacting protein; SPANK 1; Spank1; SPANK-1; SSTR-interacting protein; Sstrip; Synamon
Gene Symbols SHANK1
Host Species Rabbit
Immunogen Synthetic peptide corresponding to the C-terminal residues S(1951) G P I Y P G L F D I R S S(1964) of rat Shank1a.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 243961, 50944, 78957
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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