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Invitrogen™ SHANK2 Monoclonal Antibody (711924)
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Catalog No. PIMA524331
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100 μg
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Catalog No. Quantity
PIMA524331 100 μg
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Catalog No. PIMA524331 Supplier Invitrogen™ Supplier No. MA524331
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Description

Mouse Monoclonal Antibody

Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.

This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, and an SH3 domain. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities of the adult and developing brain. Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder. Alternative splicing results in multiple transcript variants.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SHANK2
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone 711924
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene SHANK2
Gene Accession No. Q9UPX8
Gene Alias AUTS17; cortactin SH3 domain-binding protein; cortactin-binding protein 1; CortBP1; CORTBP1CTTNBP1; CTTNBP1; GKAP/SAPAP interacting protein; GKAP/SAPAP-interacting protein; Kiaa1022; mKIAA1022; proline rich synapse associated protein 1; proline-rich synapse associated protein 1; proline-rich synapse-associated protein 1; PROSAP1; SH3 and multiple ankyrin repeat domains 2; SH3 and multiple ankyrin repeat domains protein 2; SH3/ankyrin domain gene 2; SHANK; Shank2; SPANK-3
Gene Symbols SHANK2
Host Species Mouse
Immunogen E. coli-derived recombinant human SHANK2 Lys849-Thr1029.
Purification Method Protein A/G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22941
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG1
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