Invitrogen™ SHANK2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5116834

Catalog No. PIPA5116834

Description

Positive Samples: Mouse liver, Rat liver Immunogen sequence: PFALGANKDS LSAFEYPGPK RKLYSAVPGR LFVAVKPYQP QVDGEIPLHR GDRVKVLSIG EGGFWEGSAR GHIGWFPAEC VEEVQCKPRD SQAETRADRS K.

This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, and an SH3 domain. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities of the adult and developing brain. Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder. Alternative splicing results in multiple transcript variants.

Specifications

• Antigen: SHANK2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SHANK2
• Gene Alias: AUTS17; cortactin SH3 domain-binding protein; cortactin-binding protein 1; CortBP1; CORTBP1CTTNBP1; CTTNBP1; GKAP/SAPAP interacting protein; GKAP/SAPAP-interacting protein; Kiaa1022; mKIAA1022; proline rich synapse associated protein 1; proline-rich synapse associated protein 1; proline-rich synapse-associated protein 1; PROSAP1; SH3 and multiple ankyrin repeat domains 2; SH3 and multiple ankyrin repeat domains protein 2; SH3/ankyrin domain gene 2; SHANK; Shank2; SPANK-3
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 171093, 210274, 22941
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 2.36 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q80Z38, Q9QX74, Q9UPX8
• Gene Symbols: SHANK2
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 500-600 of human SHANK2 (NP_0364412).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG