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Invitrogen™ SHANK2 Polyclonal Antibody
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Catalog No. PIPA5116834
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100 μL
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PIPA5116834 100 μL
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Catalog No. PIPA5116834 Supplier Invitrogen™ Supplier No. PA5116834
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Description

Rabbit Polyclonal Antibody

Positive Samples: Mouse liver, Rat liver Immunogen sequence: PFALGANKDS LSAFEYPGPK RKLYSAVPGR LFVAVKPYQP QVDGEIPLHR GDRVKVLSIG EGGFWEGSAR GHIGWFPAEC VEEVQCKPRD SQAETRADRS K.

This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, and an SH3 domain. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities of the adult and developing brain. Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder. Alternative splicing results in multiple transcript variants.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SHANK2
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 2.36 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene SHANK2
Gene Accession No. Q80Z38, Q9QX74, Q9UPX8
Gene Alias AUTS17; cortactin SH3 domain-binding protein; cortactin-binding protein 1; CortBP1; CORTBP1CTTNBP1; CTTNBP1; GKAP/SAPAP interacting protein; GKAP/SAPAP-interacting protein; Kiaa1022; mKIAA1022; proline rich synapse associated protein 1; proline-rich synapse associated protein 1; proline-rich synapse-associated protein 1; PROSAP1; SH3 and multiple ankyrin repeat domains 2; SH3 and multiple ankyrin repeat domains protein 2; SH3/ankyrin domain gene 2; SHANK; Shank2; SPANK-3
Gene Symbols SHANK2
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 500-600 of human SHANK2 (NP_0364412).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 171093, 210274, 22941
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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