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Invitrogen™ SHANK2 Polyclonal Antibody
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Catalog No. PIPA5101885
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PIPA5101885 100 μL
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Catalog No. PIPA5101885 Supplier Invitrogen™ Supplier No. PA5101885
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total SHANK2.

This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, and an SH3 domain. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities of the adult and developing brain. Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder. Alternative splicing results in multiple transcript variants.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SHANK2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene SHANK2
Gene Accession No. Q80Z38, Q9UPX8
Gene Alias AUTS17; cortactin SH3 domain-binding protein; cortactin-binding protein 1; CortBP1; CORTBP1CTTNBP1; CTTNBP1; GKAP/SAPAP interacting protein; GKAP/SAPAP-interacting protein; Kiaa1022; mKIAA1022; proline rich synapse associated protein 1; proline-rich synapse associated protein 1; proline-rich synapse-associated protein 1; PROSAP1; SH3 and multiple ankyrin repeat domains 2; SH3 and multiple ankyrin repeat domains protein 2; SH3/ankyrin domain gene 2; SHANK; Shank2; SPANK-3
Gene Symbols SHANK2
Host Species Rabbit
Immunogen A synthesized peptide derived from human SHANK2(Accession Q9UPX8), corresponding to amino acid residues P555-M605.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 210274, 22941
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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