SHARP Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Catalog No.	Quantity
50-155-9308	10 μL

Catalog No. 50-155-9308 Supplier Bethyl Laboratories, Inc Supplier No. A301120AT

Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt.

May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA.

Specifications

• Antigen: SHARP
• Applications: Immunoprecipitation
• Classification: Polyclonal
• Concentration: 1 mg/ml
• Conjugate: Unconjugated
• Formulation: phosphate, tris citrate with 0.09% sodium azide; pH 7-8
• Gene: SPEN
• Gene Accession No.: Q96T58
• Gene Alias: HIAA0929, KIAA0929, MINT, Msx2 interacting nuclear target (MINT) homolog, nuclear receptor transcription cofactor, RBM15C, SHARP, SMART/HDAC1-associated repressor protein, SPEN homolog, spen homolog, transcriptional regulator, spen homolog, transcriptional regulator (Drosophila)
• Gene Symbols: SPEN
• Host Species: Rabbit
• Immunogen: Between 3375 and 3425
• Purification Method: Antigen affinity chromatography
• Quantity: 10 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 23013
• Target Species: Human
• Content And Storage: 4° C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG