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SHARP Rabbit anti-Human, Polyclonal, Bethyl Laboratories
Rabbit Polyclonal Antibody
Supplier: Bethyl Laboratories, Inc A301120AT
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The recommended shelf life for this product is 1 year from date of receipt.May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA.
|HIAA0929, KIAA0929, MINT, Msx2 interacting nuclear target (MINT) homolog, nuclear receptor transcription cofactor, RBM15C, SHARP, SMART/HDAC1-associated repressor protein, SPEN homolog, spen homolog, transcriptional regulator, spen homolog, transcriptional regulator (Drosophila)|
|Antigen affinity chromatography|
|phosphate, tris citrate with 0.09% sodium azide; pH 7-8|
|Between 3375 and 3425|
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