SHARPIN Mouse anti-Human, Clone: OTI2B1, lyophilized, TrueMAB™

Catalog No.	Quantity
50-167-0744	100 μg

Catalog No. 50-167-0744 Supplier OriGene Supplier No. CF811608

Description

Mouse Monoclonal Antibody

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.

Specifications

• Antigen: SHARPIN
• Applications: Western Blot
• Classification: Monoclonal
• Clone: OTI2B1
• Conjugate: Unconjugated
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene: SHARPIN
• Gene Accession No.: Q9H0F6
• Gene Alias: SIPL1
• Gene Symbols: SHARPIN
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 1-326 of human SHARPIN produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 81858
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG2a