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SHARPIN Monoclonal Antibody (OTI2B1), TrueMAB™, OriGene
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene TA811608

Encompass_Preferred

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Catalog No. 50-168-4140


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Description

Description

Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.
Specifications

Specifications

SHARPIN
Monoclonal
Unconjugated
SHARPIN
SIPL1
Mouse
Affinity Chromatography
RUO
81858
-20° C, Avoid Freeze/Thaw Cycles
Liquid
Western Blot
OTI2B1
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Q9H0F6
SHARPIN
Human recombit protein fragment corresponding to amino acids 1-326 of human SHARPIN produced in E.coli.
100 μL
Primary
Human
Antibody
IgG2a
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